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Treatment of premenstrual tension syndrome with Vitex agnus castus
Controled, double - blind study versus pyridoxine

Published research (Treatment of premenstrual tension syndrome with VitexAgnus Castus Controlled double blind study versus pyridoxine CHLAURITZEN,H.D.REUTER,R.REPGES,K-JBOHNERT and U.SCHMIDT) reports the experience of 632 gynecologists who witnessed the use of VAC on a total of 3216 patients, of which 1542 suffered by PMS symptoms. Average age was 34,7+-10.4 years and average length of treatment 166 days. The effectiveness of VAC was confirmed by both patients and doctors. From the 1542 patients, 510 (33%) reported total lack of symptoms after treatment and 878 (57%) clear improvement. A total success of 90%. Gynecologists rated the therapy as excellent and good for a total of 1100 patients (71%) and satisfactory for 321 patients (28%). Total improvement of 99%.

Effects of Combination of Hypericum perforatum and Vitex agnus-castus on PMS - Like Symptoms in Late Perimenopausal Women--


Agnus Castus

Agnus Castus (vitex agnus castus) is a herb od the mediterranean, used trasditionnaly for the balance of women’s cycle.According to EMA (European Medicine Association) it is traditionnaly used for the relief of PMS symptoms. It is also mentioned as a monoggrphy of  German Comission E for the treatment of irregul;ar menstrual cycle, PMS and tender breasts. (7,8,14)


The results are due to the action of the plant extract on the pituitary gland.. Even though  agnus castus does not contain hormones, it stimulates the natural production of the hormones responsible for the wonens cycle. (12)


Hypothalamus and the pituitary, secreet FSH και LH hormones which in their turn stimulate the ovaries to secrete progesterone and oestrogens. (9)


There are a lot of recherches conducted on Agnus castus. The results demonstrate that the use of agnus castus improved the symptoms more than 50% of the control groups. (11,13)


It proved to be more effective from placebo, pyridoxine (B6) and magnesium. (1,2,3,4,15,16,17,18,19,20)


Due to possible dopaminergic and estrogenic action of Agnus Castus, patients using contraseptives, estrogens or contraestrogens, or dopaminergic medications, should consult their doctors since it is possible to alter their action.


Agnus Castus security has proven to be exellent with mild and generally scarce contraindications. (9,14)


Viburnum acts as anticonvulsant, tranquilizer and styptic. It has a mild analgesic action.


Powerfull uterus relaxant, reduces blood pressure, relaxes tensed muscles, suppresses  the nervous system and is especially usfull in situation when natural and psychological tensions occur as is the situation with PMS (26,27)

St Johns Wort

 St Johns Wort (Hypericum perforatum) extract has calming and soothing properties. It bounds free radicals and shows antioxidant action which also contributes in treating the PMS symptoms. (1)


 It is an effective remedy for depression –used traditionally, (21,24,25) according to ΕΜΑ (European Medicine Association) – therefore has a positive effect on the mental and psychological symptoms of PMS. (6)


Scientific research proves the positive action of St. John's Wort on PMS, on both physical and mental symptoms (1,3,22,23)


Published study demonstrates the positive effect of the combination of Agnus castus and St Johns Wort on PMS symptoms treatment (10)

Vitamine Β6

Vitamine Β6 (pyridoxine)contributes in the regulation of hormonal activity. Β6 takes part in the transformation of essential fatty acids to prostagladines, which help regulate the hormonal balance.


It also contributes to the stabilization of liquid levels in the body through its involvement in potassium/sodium balance,


Theoretically, low levels of vitamine B6 may lead in high levels of prolactine, which in turn is incriminated for PMS symptoms. (2,3,5,28,29)



Magnesium contributes to lessen fatigue symptoms, balance electrolytes, the normal function of nervous system and the normal psychological function. It also contributes to the regulation of fluid retention, cramps and cravings. (2,3,5,29)​


1. Jang et al. BMC Complementary and Alternative Medicine 2014, 14:11. Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome / premenstrual dysphoric disorder: systematic review.


2. Sarah Canning, Mitch Waterman & Louise Dye. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy. Journal of Reproductive and Infant Psychology. October 2015, At:20:48


3. Andrea Girman,MD, MPH, Roberta Lee, MD, and Benjamin Kligler, MD, MPH. An Integrative Approach to Premenstrual Syndrome. May 2003, Am J Obstet Gynecol


4. Giulia Dante & Fabio Facchinetti. Herbal treatments for alleviating premenstrual symptoms: a systemic review. Mother Infant Department, University of Modena and Reggio Emilia. November 2010


5. Andrea Rapkin. A review of treatment of premenstrual syndrome & premenstrual dysphoric disorder. Psychoneuroendocrinology 28 (2003) 39-53.


6. Maria Kleinstauber, Michael Witthoft, Wolfgang Hiller. Cognitive-Behavioral and Pharmacological Interventions for Premenstrual Syndrome or Premenstrual Dysphoric Disorder: A Meta-Analysis. J Clin Psychol Med Settings (2012) 19:308-319


7. European Medicines Agency. Community herbal monograph on Vitex agnus-castus L., fructus. Committee on Herabl Medicinal Products (HMPC). November 2010.


8. List of German Commission E Monographs (Phytotherapy). Chaste Tree fruit (Agni casti fructus). December 1992.


9. M. Diana van Die, Henry G. Burger, Helena J. Teede, Kerry M. Bone. Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials. Planta Med 2013; 79:562-575.


10. Margaret Diana van Die, Ph.D., Kerry M. Bone, B.Sc., Dip. Phyt. F.N.I.M.H., F.N.H.A.A., Henry G. Burger, M.D., F.R.A.C.P., John E. Reece, Ph.D., and Helena J. Teede, M.B.B.S., Ph.D., F.R.A.C.P. Effects of a Combination of Hypericum perforatum and Vitex agnus-castus on PMS-Like Symptoms  in Late-Perimenopausal Women: Findings from a Subpopulation Analysis. The Journal of Alternative and Complementary Medicine, Volume 15, Number 9, 2009, pp. 1045-1048


11. Mehrangiz Zamani, Nostrat Neghab, and Saadat Torabian. Therapeutic Effect of Vitex Agnus Castus in Patients with Premenstrual Syndrome. October 2011.


12. Ch. Lauritzen, H.D. Reuter, R. Repges, K.-J. Bohnert and U. Schmidt. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomedicine Vol.4 (3), pp. 183-189, 1997 by Gustav Fischer Verlag.


13. W. Wuttke, H. Jarry, V. Christoffel, B. Spengler, and D. Seidlova-Wuttke. Chaste tree (Vitex agnus- castus)-Pharmacology and clinical indications.Phytomedicine 10:348-357, 2003


14. Mikio Momoda, Hidetaka Sasaki, Eiko Tagashira, Masayuki Ogishima, Yuichi Takano, Kazunori Ochiai. Efficacy and Safety of Vitex agnus-castus Extract for Treatment of Premenstrual Syndrome in Japanese Patients: A Prospective, Open-label Study. Adv Ther (2014) 31:362-373.


15. Linlin Ma, Shouqing Lin, Rong Chen, & Xiuli Wang. Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Gynecological Endocrinology, August 2010; 26(8): 612-616.


16. Ruediger Schellenberg, Christian Zimmermann, Jurgen Drewe, Godehard Hoexter, Catherine Zahner. Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome. Phytomedicine 19 (2012) 1325-1331.


17. R. Schellenberg for the study group. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomized, placebo controlled study. BMJ V. 322, January 2001.


18. Ernst-Gerhard Loch, M.D., Harmut Selle, Ph.D., and Normann Boblitz, M.D. Treatment of Premenstrual Syndrome with a Phytopharmaceutical Formulation Containing Vitex agnus castus. Journal of Women’s Health & Gender-Based Medicine, Volume 9, Number 3, 2000.


19. R. Eltbogen, M. Litschgi, U. E. Gasser, S. Nebel and C. Zahner. Vitex Agnus-Castus (Ze 440) Improves Symptoms in Women with Menstrual Cycle Irregularities. Zeller medical.


20. Agnolyt solution, Prescribed by law in Germany.


21. European Medicines Agency, Community Herbal Monograph on Hypericum Perforatum L., Herba (Well-Established Medicinal Use).Evaluation of Medicines for Human Use. London, November 2009 Doc. Ref: EMA/HMPC)101304/2008.


22. Sarah Canning Mitch Waterman, Nic Orsi, Julie Ayres, Nigel Simpson and Louise Dye. The Efficacy of Hypericum perforatum (St John’s Wort) for the treatment of Premenstrual Syndrome. A Randomized, Double-Blind, Placebo-Controlled Trial. CNS Drugs 2010: 24(3): 207-225.


23. Clare Stevinson, Edzard Ernst. A pilot study of Hypericum perforatum for treatment of premenstrual syndrome. British Journal of Obstetrics  and Gynaecology. July 2000, Vol 107, pp. 870-876.


24. Rene Schellander, Josef Donnerer. Antidepressants: Clinically Relevant Drug Ineractions to Be Considered. Pharmacology 2010;86:203-2015.


25. SN Sim, MAH Levine. An evaluation of Pharmacist and Health Food store retailer’s knowledge regarding potentional drug interactions associated with St. John’s Wort. Can J. Clin Pharmacol Vol 17(1) Winter 2010:e57-e63;February 2010.


26. Maria Francesca Cometa, Laura Parisi, Maura Palmery, Annarita Menequz, Lamberto Tomassini. In vitro relaxant and spasmolytic effects of consituents from Viburnum prunifolium and HPLC quantification of the bioactive isolated iridoids. Journal of Ethnopharmacology 123 (2009) 201-207.


27. Carolyn Dean, Susan K. Steinberg, William H. Sylvester. Medical Management of Premenstrual Syndrome. Can. Fam. Physician Vol.32: April 1986;32:841-852.


28. M. Kashanian, R. Mazinani, S. Jalalmanesh. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Brief Communications,September 2006.


29. Nahid Fathizadeh, MSc, Elham Ebrahimi, Mahboube Valiani, MSc, Naser Tavakoli, PhD, and Mazizhe Hojat Yar, BS. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010 Dec; 15 (Suppl1):401-405..